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The triggering mechanism for the most luminous, quasar-like active galactic nuclei (AGN) remains a source of debate, with some studies favouring triggering via galaxy mergers, but others finding little evidence to support this mechanism. Here, we present deep Isaac Newton Telescope/Wide Field Camera imaging observations of a complete sample of 48 optically selected type 2 quasars – the QSOFEED sample ($L_{\rm [O\, \small {III}]}\gt 10^{8.5}\, \mathrm{L}_{\odot }$; z < 0.14). Based on visual inspection by eight classifiers, we find clear evidence that galaxy interactions are the dominant triggering mechanism for quasar activity in the local universe, with 65$^{+6}_{-7}$ per cent of the type 2 quasar hosts showing morphological features consistent with galaxy mergers or encounters, compared with only 22$^{+5}_{-4}$ per cent of a stellar-mass- and redshift-matched comparison sample of non-AGN galaxies – a 5σ difference. The type 2 quasar hosts are a factor of 3.0$^{+0.5}_{-0.8}$ more likely to be morphologically disturbed than their matched non-AGN counterparts, similar to our previous results for powerful 3CR radio AGN of comparable [O iii] emission-line luminosity and redshift. In contrast to the idea that quasars are triggered at the peaks of galaxy mergers as the two nuclei coalesce, and only become visible post-coalescence, the majority of morphologically disturbed type 2 quasar sources in our sample are observed in the pre-coalescence phase (61$^{+8}_{-9}$ per cent). We argue that much of the apparent ambiguity that surrounds observational results in this field is a result of differences in the surface brightness depths of the observations, combined with the effects of cosmological surface brightness dimming.

 

In many tissues, cell type varies over single-cell length-scales, creating detailed heterogeneities fundamental to physiological function. To gain understanding of the relationship between tissue function and detailed structure, and eventually to engineer structurally and physiologically accurate tissues, we need the ability to assemble 3D cellular structures having the level of detail found in living tissue. Here we introduce a method of 3D cell assembly having a level of precision finer than the single-cell scale. With this method we create detailed cellular patterns, demonstrating that cell type can be varied over the single-cell scale and showing function after their assembly. 

We investigate the abundance and distribution of metals in the high-redshift intergalactic medium and circum-galactic medium through the analysis of a sample of almost 600 Si iv absorption lines detected in high- and intermediate-resolution spectra of 147 quasars. The evolution of the number density of Si iv lines, the column density distribution function, and the cosmic mass density are studied in the redshift interval 1.7 ≲ z ≲ 6.2 and for log N(Si iv) ≥ 12.5. All quantities show a rapid increase between z ∼ 6 and z ≲ 5 and then an almost constant behaviour to z ∼ 2 in very good agreement with what is already observed for C iv absorption lines. The present results are challenging for numerical simulations: When simulations reproduce our Si iv results, they tend to underpredict the properties of C iv, and when the properties of C iv are reproduced, the number of strong Si iv lines [log N(Si iv) > 14] is overpredicted.

 

With improving biofabrication technology, 3D bioprinted constructs increasingly resemble real tissues. However, the fundamental principles describing how cell-generated forces within these constructs drive deformations, mechanical instabilities, and structural failures have not been established, even for basic biofabricated building blocks. Here we investigate mechanical behaviours of 3D printed microbeams made from living cells and extracellular matrix, bioprinting these simple structural elements into a 3D culture medium made from packed microgels, creating a mechanically controlled environment that allows the beams to evolve under cell-generated forces. By varying the properties of the beams and the surrounding microgel medium, we explore the mechanical behaviours exhibited by these structures. We observe buckling, axial contraction, failure, and total static stability, and we develop mechanical models of cell-ECM microbeam mechanics. We envision these models and their generalizations to other fundamental 3D shapes to facilitate the predictable design of biofabricated structures using simple building blocks in the future.

 

Three-dimensional (3D) printing has expanded beyond the mere patterned deposition of melted solids, moving into areas requiring spatially structured soft matter—typically materials composed of polymers, colloids, surfactants, or living cells. The tunable and dynamically variable rheological properties of soft matter enable the high-resolution manufacture of soft structures. These rheological properties are leveraged in 3D printing techniques that employ sacrificial inks and sacrificial support materials, which go through reversible solid–fluid transitions under modest forces or other small perturbations. Thus, a sacrificial material can be used to shape a second material into a complex 3D structure, and then discarded. Here, we review the sacrificial materials and related methods used to print soft structures. We analyze data from the literature to establish manufacturing principles of soft matter printing, and we explore printing performance within the context of instabilities controlled by the rheology of soft matter materials.